David Quammen talks about his latest book, Spillover: Animal Infections and the Next Human Pandemic.From his Web site: "The next big and murderous human pandemic, the one that kills us … Plasmodium knowlesi, previously thought to only affect macaques, caused 66 per cent of Malaysia’s malaria cases last yea on p48) chromosomes to create new stable variants that can be fatal to humans. It is caused by a parasite called Plasmodium. People continue to take the drug while they remain in an area where malaria is … These claims have been confirmed with more modern methodologies. The Duffy blood group plays a key role in Plasmodium knowlesi and Plasmodium vivax invasion into human erythrocytes. Since birds do not obey geographic borders, the virus has caused flu globally. The precivilization origins of both P. falciparum [5, 6] and P. vivax [7, 8] — pandemic malaria parasites, which underlie the majority of human malaria infections globally [2, 9] — have recently been traced to African …
However, another relatively new species, Plasmodium knowlesi, is also a dangerous species that is typically found only in long-tailed and pigtail macaque monkeys. However, it is possible to express no Duffy antigen on red blood cells (Fy-/Fy-). Like P. falciparum, P. knowlesi may be deadly to anyone infected. Monkey malaria in humans on the rise Plasmodium knowlesi, previously thought to only affect macaques, caused 66 per cent of Malaysia’s malaria cases last year For example, the zoonotic potential of the primate malaria species Plasmodium knowlesi was suspected as early as 1932 (Schwabe, 1984, Conlan et al., 2011) but human cases were greatly underestimated until the advent of appropriate molecular tools (Singh et al., 2004, Conlan et al., 2011). However, recent advances in molecular diagnostics and the expanded sampling of wild primates have revealed that P. knowlesi is not the only malaria parasite to transcend species boundaries. The parasite is spread to people by the female Anopheles mosquito, which feeds on human blood.

In vector-borne disease systems, there is mounting evidence that vertebrate hosts become more attractive to disease vectors during infection, yet in human malaria, the underlying mechanism has not been studied.
The other three common species of malaria (P. vivax, P. malariae, and P. ovale) are generally less serious and are usually not life-threatening. The four main Plasmodium species that cause human malaria, Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium ovale, are transmitted between humans by mosquito vectors belonging to the genus Anopheles.It has recently become evident that Plasmodium knowlesi, a parasite that typically infects forest macaque monkeys, can be transmitted by …

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